About the six MPRINT Hub cores
There are six MPRINT Hub Scientific Cores, each with unique challenges and developments underway.
- Knowledgebase & Portal Core is developing a knowledgebase of data and resources relating to maternal and pediatric therapeutics, including pharmacokinetics, pharmacodynamics, pharmacogenetics, pediatric ontogeny and the physiological changes that occur with and around pregnancy and lactation. The Knowledgebase & Portal Core is developing common data elements and ontologies for annotating these data; developing text classification algorithms to identify relevant published literature; and integrate various data sources into an accessible web portal.
Contact: Lang Li, PhD Lang.Li@osumc.edu
- Pharmacometrics & Clinical Trial Design Core provides expertise in pharmacokinetic (PK) and pharmacodynamic (PD) modeling, biostatistics, and clinical trial design. The Pharmacometrics & Clinical Trial Design Core supports clinical pharmacology study design and pharmacometric modeling approaches including population pharmacokinetics (PK), physiologically based (or mechanistic) PK/PD, machine learning, pharmacogenomics (PG), and Bayesian methods and adaptive trial design. The core will support development of open-source PBPK/PD models in pregnancy, lactation, and pediatrics that integrate in vitro, in vivo, and physiologic data to interrogate changes in PK/PD across the maternal and pediatric lifespan.
Contact: Sara Quinney, PharmD, PhD squinney@iu.edu
- Real-World Evidence Core brings together experts and resources from the Regenstrief Institute at Indiana University, the Indiana Health Information Exchange (IHIE), and Information Technology groups across our partner healthcare systems, Nationwide Children’s Hospital and Ohio State University. They can support a variety of studies through leveraging and building upon expertise and robust real-world data resources.
Contact: Shaun Grannis, sgrannis@regenstrief.org
- Phenotyping Core at Vanderbilt University Medical Center provides expertise in using electronic health records, including Vanderbilt’s BioVU biobank resource, and techniques like clinical terminologies, natural language processing, and machine learning to better understand response to medications.
Contact: WeiQi Wei MD, PhD wei-qi.wei@vumc.org and Henry Ong, PhD henry.ong@vumc.org
- Milk Analytics Core has expertise in collecting and processing human milk samples and performing a variety of human milk assays including macronutrients, oligosaccharides, microbiomes, and other multiplex assays.
Contact: Lars Bode lbode@ucsd.edu
- Pharmacometric and Analytical Chemistry Core is housed within the UCSD Pediatric Pharmacology Laboratory and performs quantitative drug and metabolite assays in small sample volumes and heterogenous matrices, including plasma, tissue, and breast milk.
Contact: Jeremiah Momper jmomper@health.ucsd.edu