Improving therapeutics implementation and outcomes by using large electronic datasets
The theme of the Vanderbilt Center of Excellence is to improve precision therapeutics implementation and outcomes through the use of large electronic datasets.
One of our goals is to address key knowledge gaps in pharmacogenomics applications for women and children, with a focus on those from populations who have been understudied in genetics.
Another goal is to evaluate the effectiveness of maternal pharmacotherapy for opioid use disorder on “real world” outcomes for pregnant women and infants.
In reaching these goals, the Vanderbilt Center of Excellence will leverage innovative data science methodologies such as the use of machine learning and natural language processing and develop tools to identify children and women with drug exposures and the outcomes after those exposures. These technologies will enhance clinical research in pharmacogenomics, opioid use disorder, and broader precision therapeutics research.
Co-directed by Prince Kannankeril, MD, MSCI, professor of Pediatrics, and Digna Velez Edwards, PhD, MS, professor of Obstetrics and Gynecology, the Vanderbilt center aims to study how to improve the implementation of precision therapeutics, or personalized medicine, for pregnant women and children, and explore long-term outcomes for the two populations.