IU-OSU Coordination Center

The IU-OSU MPRINT DMKRCC (Data and Model Knowledge and Research Coordination Center) is co-directed by Sara K. Quinney, PharmD, PhD, Associate Professor of OB/GYN and Medicine (Clinical Pharmacology), Indiana University School of Medicine, and Lang Li, PhD, Professor and Chair, Department of Biomedical Informatics, College of Medicine, The Ohio State University.

Together, we’re supporting, coordinating, and expanding research relating to maternal and pediatric therapeutics within the MPRINT Hub and partner organizations.

The IU-OSU DMKRCC is composed of five cores:

Logistics Core, led by Drs. Sara Quinney and Lang Li, provides overall logistic support and administrative coordination of the MPRINT Hub.

The Logistics Core facilitates interactions among MPRINT Hub members and partners to promote and support multidisciplinary research efforts in maternal and pediatric therapeutics.
Outreach Core is led by Dr. Sara Quinney and serves as a conduit between the MPRINT Hub and the broader scientific community.

The Outreach Core will facilitate interactions with external partners to enhance knowledge, research, and educational efforts in maternal and pediatric therapeutics.
Knowledgebase & Portal Core led by Dr. Lang Li at The Ohio State University will develop a knowledgebase of data and resources relating to maternal and pediatric therapeutics, including pharmacokinetics, pharmacodynamics, pharmacogenetics, pediatric ontogeny and the physiological changes that occur with and around pregnancy and lactation.

The Knowledgebase & Portal Core will develop common data elements and ontologies for annotating these data; develop text classification algorithms to identify relevant published literature; and integrate various data sources into an accessible web portal.

Pharmacometrics & Clinical Trial Design Core is led by Drs. Robert Bies and Sara Quinney and will provide expertise in pharmacometrics and clinical trial design relating to maternal and pediatric therapeutics. The Pharmacometrics & Clinical Trial Design Core will support development of pharmacometric models in pregnant and lactating women and children to provide mechanistic insight into changes in drug disposition and response across the lifespan and sources of inter- and intra-individual variability.

By bringing together pharmacometricians and clinical pharmacologists with expertise in obstetrics and pediatrics, the it will serve as a national and international resource for maternal and pediatric therapeutics by enhancing model informed drug development, clinical study design and personalized pharmacotherapy through implementation of novel pharmacometric modeling approaches.
Real-world Evidence Core, led by Drs. Shaun Grannis and Christopher Bartlett, brings together experts and resources from the Regenstrief Institute at Indiana University, the Indiana Health Information Exchange (IHIE), and Information Technology groups across our partner healthcare systems with Nationwide Children’s Hospital and Ohio State University.

By leveraging and building upon our team’s expertise and robust real-world data resources, we will support MPRINT investigators to characterize, study and address research questions on maternal and pediatric physiology, pharmacology, and clinical outcomes, including social and health disparities issues, with the ultimate goal of enhancing drug safety and efficacy in maternal and pediatric patients by understanding inter-and intra-individual sources of variability.

A doctor leans down to smile at a baby during a checkup examination.

A baby nurses while being held in their mother's arms

A doctor uses a tongue depressor to look in the throat of a pre-teen boy during a checkup exam.

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IU-OSU Coordination Center

The IU-OSU DMKRCC is composed of five cores:

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IU-OSU Coordination Center

The IU-OSU DMKRCC is composed of five cores:

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