The MPRINT Hub comprises the Indiana University-Ohio State University Data and Model Knowledge and Research Coordination Center (IU-OSU DMKRCC) and two Centers of Excellence (CETs). All the research done by the members creates a real-world impact in maternal and pediatric therapeutics.
Read more below about the MPRINT Hub:
| Full Citation | DOI Link |
| Yue M, Kus L, Katta S, Su I, Li L, Haas DM, Quinney SK. Pharmacokinetics of Antidepressants in Pregnancy. J Clin Pharmcol. 2023 Jun; 63 Suppl 1 (Suppl 1): S137-S158. doi: 10.1002/jcph.2282. PMID: 3717494; PMCID: PMC 10442696. | Link |
| The MPRINT Hub Data, Model, Knowledge and Research Coordination Center: Bridging the gap in maternal-pediatric therapeutics research through data integration and pharmacometrics. Quinney SK, Bies RR, Grannis SJ, Bartlett CW, Mendonca E, Rogerson CM, Backes CH, Shah DK, Tillman EM, Costantine MM, Aruldhas BW, Allam R, Grant A, Abbasi MY, Kandasamy M, Zang Y, Wang L, Shendre A, Li L. Pharmacotherapy, 10 Jan 2023. | Link |
| A Population pharmacokinetic model based on HPTN 077 of long-acting injectable Cabotegravir for HIV PrEP. Yifan Yu, Kristin L Bigos, Mark A Marzinke, Raphael J. Landovitz, Marybeth McCauley, Susan Ford, Craig W. Hendrix, Robert R. Bies, Ethel D. Weld, HPTN 077 Study Team. Br J Clin Pharmacol | Link |
| Full Citation | DOI Link |
| Bode L, Bertrand K, Najera JA, Furst A, Honerkamp-Smith G, Shandling AD, Chambers CD, Camerini D, Campo JJ. Characterization of SARS-CoV-2 antibodies in human milk from 21 women with confirmed COVID-19 infection. Pediatr Res. 2022 Nov 25:1–8. doi: 10.1038/s41390-022-02360-w. Epub ahead of print. PMID: 36434204; PMCID: PMC9702863 | Link |
| Bertrand K, Rossi S, Wells A, Best B, Chambers CD. The Concentration of Etanercept in Human Milk and Infant Outcomes. J Rheumatol. 2022 Nov 15:jrheum.220724. doi: 10.3899/jrheum.220724. Epub ahead of print. PMID: 36379569. | Link |
| Luskin K, Mortazavi D, Bai-Tong S, Bertrand K, Chambers C, Schulkers-Escalante K, Ahmad A, Luedtke S, O'Donoghue AJ, Ghassemian M, Geng B, Leibel SL, Leibel SA. Allergen Content and Protease Activity in Milk Feeds from Mothers of Preterm Infants. Breastfeed Med. 2022 Oct 12. doi: 10.1089/bfm.2022.0115. Epub ahead of print. PMID: 36251466. | Link |
| Transfer of antibiotics and their metabolites in human milk: implications for infant health and microbiota. Sydney P. Thomas, Erce Denizer, Simone Zuffa, Brookie M. Best, Lars Bode, Christina D. Chambers, Pieter C. Dorrestein, George Y. Liu, Jeremiah D. Momper, Victor Nizet, Shirley M. Tsunoda, Adriana H. Tremoulet. Accepted by Pharmacotherapy. | Link |
| An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant. Sydney Thomas, Julia M. Gauglitz, Anupriya Tripathi, Fernando Vargas, Karri Bertrand, Jae H Kim, Christina Chambers, Pieter C. Dorrestein, Shirley M. Tsunoda. Clin Transl Sci. | Link |
| Human Milk Oligosaccharides Reduce Murine Group B Streptococcus Vaginal Colonization with Minimal Impact on the Vaginal Microbiota. Marlyd E. Mejia, Samantha Ottinger, Alison Vrbanac, Priyanka Babu, Jacob J. Zulk, David Moorshead, Lars Bode, Victor Nizet, Kathryn A. Patras. mSphere | Link |
| Full Citation | DOI Link |
| Monika E Grabowska, Sara L Van Driest, Jamie R Robinson, Anna E Patrick, Chris Guardo, Srushti Gangireddy, Henry H Ong, QiPing Feng, Robert Carroll, Prince J Kannankeril, Wei-Qi Wei, Developing and evaluating pediatric phecodes (Peds-Phecodes) for high-throughput phenotyping using electronic health records, Journal of American Medical Informatics Association, 2023;,ocad233 | Link |
| Antoon JW, Grijalva CG, Johnson J, Carroll AR, Stassun JC, Bonnett K, Schlundt D, Williams DJ. Parental Perceptions of Penicillin Allergy Risk Stratification and Delabeling. Hosp Pediatr. 2023 Mar 15:e2022006737. doi: 10.1542/hpeds.2022-006737. | Link |
| Antoon JW, Feinstein JA, Kyler K, Goldman JL, Shah SS on behalf of the Children’s Hospital Association Pharmacoepidemiology and Medication Safety (Peds-Rx) Research Group. Advancing Pediatric Medication Safety Using Real-World Data: Current Problems and Potential Solutions. J Hosp Med. 2023 Feb 28. doi: 10.1002/jhm.13068. | Link |
| Xiao B, Velez Edwards DR, Lucas A, Drivas T, Gray K, Keating B, Weng C, Jarvik GP, Hakonarson H, Kottyan L, Elhadad N, Wei WQ, Luo Y, Kim D, Ritchie M, Verma SS; Regeneron Genetics Center *. Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female-Specific Health Conditions. J Am Heart Assoc. 2023 Mar 7;12(5):e026561. doi: 10.1161/JAHA.121.026561. Epub 2023 Feb 27. PMID: 36846987 | Link |
| Jennifer A Pacheco, Luke V Rasmussen, Ken Wiley Jr, Thomas Nate Person, David J Cronkite, Sunghwan Sohn, Shawn Murphy, Justin H Gundelach, Vivian Gainer, Victor M Castro, Cong Liu, Frank Mentch, Todd Lingren, Agnes S Sundaresan, Garrett Eickelberg, Valerie Willis, Al’ona Furmanchuk, Roshan Patel, David S Carrell, Yu Deng, Nephi Walton, Benjamin A Satterfield, Iftikhar J Kullo, Ozan Dikilitas, Joshua C Smith, Josh F Peterson, Ning Shang, Krzysztof Kiryluk, Yizhao Ni, Yikuan Li, Girish N Nadkarni, Elisabeth A Rosenthal, Theresa L Walunas, Marc S Williams, Elizabeth W Karlson, Jodell E Linder, Yuan Luo, Chunhua Weng, WeiQi Wei, Evaluation of the portability of computable phenotypes with natural language processing in the eMERGE network, Nature Sci Rep. 2023 Feb 3;13(1):1971. doi: 10.1038/s41598-023-27481-y., PMID: 36737471 PMCID: PMC9898520 | Link |
| Floyd BJ, Weile J, Kannankeril PJ, et al. Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest. Circ Genom Precis Med. 2023 Feb;16(1):e003792. PMID: 36716194; PMCID: PMC9974880. | Link |
| Sundermann AC, Slaughter JC, Velez Edwards DR, Hartmann KE. Time-Varying Exposures and Miscarriage: A Comparison of Statistical Models Through Simulation. Am J Epidemiol. 2023 Jan 30:kwad021. doi: 10.1093/aje/kwad021. Online ahead of print. PMID: 36721373 | Link |
| Pham A, Wiese AD, Spieker AJ, Phillips SE, Adgent MA, Grijalva CG, Osmundson SS. Social Vulnerability and Initiation of Pharmacotherapy for Gestational Diabetes Mellitus in a Medicaid Population. Womens Health Issues. 2023 Jan 19:S1049-3867(22)00180-3. doi: 10.1016/j.whi.2022.12.004. Epub ahead of print. PMID: 36681526. | Link |
| Jasper EA, Hellwege JN, Piekos JA, Jones SH, Hartmann KE, Mautz B, Aronoff DM, Edwards TL, Velez Edwards DR. Genetically-predicted placental gene expression is associated with birthweight and adult body mass index. Sci Rep. 2023 Jan 6;13(1):322. doi: 10.1038/s41598-022-26572-6. PubMed PMID: 36609580; PubMed Central PMCID: PMC9822919. | Link |
| Linder JE, Allworth A, Bland ST, Caraballo PJ, Chisholm RL, Clayton EW, Crosslin DR, Dikilitas O, DiVietro A, Esplin ED, Forman S, Freimuth RR, Gordon AS, Green R, Harden MV, Holm IA, Jarvik GP, Karlson EW, Labrecque S, Lennon NJ, Limdi NA, Mittendorf KF, Murphy SN, Orlando L, Prows CA, Rasmussen LV, Rasmussen-Torvik L, Rowley R, Sawicki KT, Schmidlen T, Terek S, Veenstra D, Velez Edwards DR, Absher D, Abul-Husn NS, Alsip J, Bangash H, Beasley M, Below JE, Berner ES, Booth J, Chung WK, Cimino JJ, Connolly J, Davis P, Devine B, Fullerton SM, Guiducci C, Habrat ML, Hain H, Hakonarson H, Harr M, Haverfield E, Hernandez V, Hoell C, Horike-Pyne M, Hripcsak G, Irvin MR, Kachulis C, Karavite D, Kenny EE, Khan A, Kiryluk K, Korf B, Kottyan L, Kullo IJ, Larkin K, Liu C, Malolepsza E, Manolio TA, May T, McNally EM, Mentch F, Miller A, Mooney SD, Murali P, Mutai B, Muthu N, Namjou B, Perez EF, Puckelwartz MJ, Rakhra-Burris T, Roden DM, Rosenthal EA, Saadatagah S, Sabatello M, Schaid DJ, Schultz B, Seabolt L, Shaibi GQ, Sharp RR, Shirts B, Smith ME, Smoller JW, Sterling R, Suckiel SA, Thayer J, Tiwari HK, Trinidad SB, Walunas T, Wei WQ, Wells QS, Weng C, Wiesner GL, Wiley K, Peterson JF. Returning integrated genomic risk and clinical recommendations: The eMERGE study. Genet Med. 2023 Jan 6;25(4):100006. doi: 10.1016/j.gim.2023.100006. [Epub ahead of print] PubMed PMID: 36621880. | Link |
| Kyler KE, Hall M, Antoon JW, Goldman J, Grijalva CG, Shah SS, Tang Girdwood S, Williams DJ, Feinstein JA. Polypharmacy among medicaid-insured children with and without documented obesity. Pharmacotherapy. 2022 Dec 23. doi: 10.1002/phar.2755 | Link |
| Hill KD, Kannankeril PJ, Jacobs JP, et al. Methylprednisolone for Heart Surgery in Infants - A Randomized, Controlled Trial. N Engl J Med. 2022 Dec 8;387(23):2138-2149. PMID: 36342116; PMCID: PMC9843240. | Link |
| Wisotzkey AK, Leech AA, Graves AR, Lwelu CC, Pourali SP, Osmundson SS. Obstetrical clinician opioid prescribing perspectives after cesarean delivery in Tennessee. 2022 Dec 9. American Journal of Obstetrics and Gynecology, Maternal-Fetal Medicine (AJOG-MFM). doi: https://doi.org/10.1016/j.ajogmf.2022.100835 | Link |
| Nicholas C Wan, Ali A Yaqoob, Henry H Ong, Juan Zhao, Wei-Qi Wei, Evaluating resources composing the PheMAP knowledge base to enhance high-throughput phenotyping, Journal of the American Medical Informatics Association, ocac234, https://doi.org/10.1093/jamia/ocac234, 2022, PMID: 36451277 | Link |
| Tutorial: Using Community Engagement Studios to Enhance Pharmacogenetic Study Design for Maximizing Enrollment of Diverse Children and Pregnant People. Elizabeth A. Jasper, Sabrina E. Holley, Sarah H. Jones, Michelle Liu, Tiffany Israel, Sara L. Van Driest, and Digna R. Velez Edwards. Clin Pharmacol Ther. | Link |
| Jasper EA, Holley SE, Jones SH, Liu M, Israel T, Van Driest SL, Velez Edwards DR. Tutorial: Using Community Engagement Studios to Enhance Pharmacogenetic Study Design for Maximizing Enrollment of Diverse Children and Pregnant People. Clin Pharmacol Ther. 2023 Mar;113(3):607-614. doi: 10.1002/cpt.2792. Epub 2022 Nov 24. PubMed PMID: 36366911; PubMed Central PMCID: PMC9957793. | Link |
| Pediatric CYP2D6 metabolizer status and post-tonsillectomy nausea and vomiting after ondansetron. Katherine Black, B. Randall Brenn, Andrea Gaedigk, Jonathan P. Wanderer, Sara L. Van Driest. Clin Transl Sci | Link |
| Antoon JW, Hall M, Howard L, Herndon AC, Freundlich KC, Grijalva CG, Williams DJ. COVID-19 and Acute Neurologic Complications in Children and Adolescents. Pediatrics. 2022 Nov 1;150(5):e2022058167. | Link |
| Kikano S, Kannankeril PJ. Precision Medicine in Pediatric Cardiology. Pediatr Ann. 2022 Oct;51(10):e390-e395. PMID: 36215086. | Link |
| Abraham A, Le B, Kosti I, Straub P, Velez Edwards DR, Davis LK, Newton JM, Muglia LJ, Rokas A, Bejan CA, Sirota M, Capra JA. Dense phenotyping from electronic health records enables machine learning-based prediction of preterm birth. BMC Med. 2022 Sep 28;20(1):333. doi: 10.1186/s12916-022-02522-x. PMID: 36167547 | Link |
| Antoon JW, Hall M, Grijalva CG, Goldman JL, Kyler K, Tang-Girdwood S, Shah SS, Feinstein JA, Williams DJ. Guideline Concordant Antiviral Treatment in Children at High-risk for Influenza Complications. Clin Infect Dis. 2023 Feb 8;76(3):e1040-e1046. doi: 10.1093/cid/ciac606. | Link |
| Influence of CYP2D6 genetic variation on adverse events with propafenone in the pediatric and young adult population. Sudeep D. Sunthankar, Prince J. Kannankeril, Andrea Gaedigk, Andrew E. Radbill, Frank A. Fish, Sara L. Van Driest. Clin Transl Sci. | Link |
| Pham A, Polic A, Nguyen L, Thompson JL. Statins in Pregnancy: Can We Justify Early Treatment of Reproductive Aged Women? Curr Atheroscler Rep. 2022 Jun 14 | Link |
| Sundermann AC, Velez Edwards DR, Hartmann KE. Maternal alcohol metabolism predicted by alcohol dehydrogenase genotype and the association between alcohol consumption and miscarriage. Am J Obstet Gynecol. 2022 May 18:S0002-9378(22)00374-X. doi: 10.1016/j.ajog.2022.05.030. Online ahead of print. PMID: 35597276 | Link |
| Sunthankar SD, Kannankeril PJ, Gaedigk A, et al. Influence of CYP2D6 genetic variation on adverse events with propafenone in the pediatric and young adult population. Clin Transl Sci. 2022 Jul;15(7):1787-1795. PMID: 35514162; PMCID: PMC9283732. | Link |
| Williams ML, Kannankeril PJ, Breeyear JH, et al. Effect of CYP3A5 and CYP3A4 Genetic Variants on Fentanyl Pharmacokinetics in a Pediatric Population. Clin Pharmacol Ther. 2022 Apr;111(4):896-908. PMID: 34877660; PMCID: PMC8940650. | Link |
| Pham A, Aronoff D, Thompson J. Review of maternal COVID-19 disease, vaccination safety in pregnancy, and evidence of protective immunity, J Allergy Clin Immunol, Volume 148, Issue 3, Pages 728-731, Sept 2021 | Link |
